MERFISH Report
1. Overview
1.1 Sample Information
A brief sample information is generated from the submission table for the following analysis.
| Expt | Sample | Genotype | DataPath | Region |
|---|---|---|---|---|
| 1 | 011_GFP | GFP | Z:/Lab/MERFISH_Imaging_data/202402181603_20240218Julio011n009VZG191m500x01_VMSC00101 | region_1 |
| 1 | 009_GFP-cre | GFPcre | Z:/Lab/MERFISH_Imaging_data/202402181603_20240218Julio011n009VZG191m500x01_VMSC00101 | region_0 |
| 2 | 008_GFP-cre | GFPcre | Z:/Lab/MERFISH_Imaging_data/202402181602_20240218Julio724n008VZG191m500x02_VMSC05201 | region_1 |
| 2 | 724_GFP | GFP | Z:/Lab/MERFISH_Imaging_data/202402181602_20240218Julio724n008VZG191m500x02_VMSC05201 | region_0 |
1.2 MERSCOPE Data Quality Summary
The summaries present the data quality assessment automatically generated by MERSCOPE for each experiment. We mainly focus on the transcripts level for each sample. So we’re looking for high density in transcripts, based on the transcripts count per field of view (FOV), transcript density in FOV, and frequency of transcripts detected.
Need to note that the low accuracy in DAPI cell boundary is not a concern, as a self-designed cell segmentation processing will take over this task.
MERSCOPE Data Quality Summary
MERSCOPE Data Quality Summary
MERSCOPE Data Quality Summary
MERSCOPE Data Quality Summary
2. Data Processing & Analysis
2.1 Cell Segmentation
Based on the spatial information and images obtained from MERFISH, we developed a machine learning model using the Cellpose algorithm to distinguish individual cells via MERFISH DAPI images.
To ensure the data quality and accuracy of cells, we have defined the minimum and maximum values for cell volume and gene count per cell. The cell volume should be between [100, 1800], and the gene count per cell > 25. After filter the outliers, the qualified cells count is shown in the following table.
2.2 Batch Effect & Dimension Reduction
We use Scanpy for the analysis of single-cell level transcriptome data. The initial stage of our analysis involves the elimination of batch effects, thereby ensuring that different samples from various batches are distributed within the same domain and are statistically reasonable to be integrated and compared. To achieve this, we utilize the Harmony algorithm.
Subsequently, we present visualizations of the batch difference by Leiden UMAP clusters. Also, we illustrate the distributions of the Leiden clusters for future analysis.
3. Cell Annotation
We use a recent published tool: Map My Cell to perform cell type annotations for each cell. It is a high resolution cell type annotator build by Alan Institude, with nested levels of classification including 34 classes and 338 subclasses.
The taxonomy is based on the Allen Mouse Brain Common Coordinate Framework version 3 (CCFv3). Part of the used abbreviations is list in the supplementary Abbreviation. Otherwise can be found in CCFv3 paper.
With the annotation, we can identify and plot the selected types of cells in each sample.
3.1 Cell Annotation (Low resolution)
3.2 Cell Annotation (High resolution)
3.3 Finalized cell type Umap
3.4 Spatial cell type (All)
3.5 Spatial cell type (Glut)
3.6 Spatial cell type (Non-Neuron)
3.7 Cell Type Qualification Analysis
| cell_type_3 | 008_GFP-cre | 009_GFP-cre | 011_GFP | 724_GFP | Total |
|---|---|---|---|---|---|
| Astrocyte | 3360 | 5338 | 7692 | 2803 | 19193 |
| CA1 Glut | 159 | 114 | 682 | 249 | 1204 |
| CA3 Glut | 490 | 414 | 582 | 395 | 1881 |
| CB Neuron | 1699 | 1292 | 1615 | 1723 | 6329 |
| CHOR | 147 | 153 | 201 | 225 | 726 |
| DG Glut | 342 | 25 | 1006 | 520 | 1893 |
| Endothelial | 2581 | 4186 | 5469 | 3467 | 15703 |
| L2/3 IT Glut | 1881 | 1548 | 2495 | 1279 | 7203 |
| L4/5 IT Glut | 2846 | 2454 | 3958 | 2825 | 12083 |
| L5 ET Glut | 404 | 252 | 538 | 396 | 1590 |
| L6 CT Glut | 1241 | 1050 | 1848 | 1404 | 5543 |
| L6 IT Glut | 1197 | 945 | 1268 | 845 | 4255 |
| L6b Glut | 412 | 288 | 503 | 384 | 1587 |
| MY/MB/P/HY Neuron | 7853 | 5372 | 6831 | 6434 | 26490 |
| Microglia | 2447 | 5757 | 2869 | 1238 | 12311 |
| OPC | 1545 | 2180 | 1827 | 1182 | 6734 |
| Oligo | 5533 | 7950 | 11234 | 8013 | 32730 |
| Pericyte | 980 | 1634 | 2215 | 1495 | 6324 |
| Pvalb GABA | 609 | 500 | 792 | 615 | 2516 |
| STR Neuron | 5084 | 4283 | 6245 | 4599 | 20211 |
| SUB Glut | 56 | 12 | 82 | 64 | 214 |
| Sst GABA | 708 | 539 | 731 | 552 | 2530 |
| TH Neuron | 767 | 767 | 1344 | 1020 | 3898 |
| VLMC | 425 | 862 | 1441 | 427 | 3155 |
| Vip/Lamp5/Sncg GABA | 476 | 461 | 818 | 410 | 2165 |
| Total | 43242 | 48376 | 64286 | 42564 | 198468 |
3.8 Cell Type Proportion Analysis
Based on the quantification of individual cell types, we are capable to compare the differences in cell numbers between various samples and genotypes. The proportion of each cell type is calculated by dividing the count of that specific cell type by the total cell count. The results are then visualized in a bar plot.
Notably, B cells, mast cells, and T cells show an obvious increase in tumor samples.
4. Gene differentiation (GFP-Cre v.s. GFP)
Here, we use Wilcoxon rank-sum test to compute gene differential expression (DE). P value are adjusted using Benjamini–Hochberg procedure. The statistical significance was cut-off by log2(Fold Change) > 2 or log2(Fold Change) < -2 and p_value < 0.05.
The result are visualized via Volcano plot: a type of scatterplot that shows statistical significance (P value) versus magnitude of change (fold change).
The comparison is between GFP-Cre and GFP samples. A positive fold change means higher expression in the tumor group.
4.1 Astrocyte
| names | scores | logfoldchanges | pvals | pvals_adj |
|---|---|---|---|---|
| Cd74 | 12.086074 | 3.327578 | 0.0000000 | 0.0000000 |
| Cxcl10 | 4.140793 | 2.956832 | 0.0000346 | 0.0001602 |
| Clec7a | 2.791419 | 2.463387 | 0.0052477 | 0.0191524 |
| C3 | 7.554973 | 2.390071 | 0.0000000 | 0.0000000 |
| Lcn2 | 3.263298 | 2.218016 | 0.0011012 | 0.0044766 |
| Serpina3n | 15.881881 | 1.702190 | 0.0000000 | 0.0000000 |
| Npas1 | 3.074245 | 1.395589 | 0.0021104 | 0.0081168 |
| Ctss | 11.239871 | 1.059485 | 0.0000000 | 0.0000000 |
| Bcan | -42.966170 | -1.050833 | 0.0000000 | 0.0000000 |
| Cspg5 | -30.998905 | -1.033761 | 0.0000000 | 0.0000000 |
| Icam1 | 4.698708 | 1.012976 | 0.0000026 | 0.0000135 |
4.2 CA1 Glut
| names | scores | logfoldchanges | pvals | pvals_adj |
|---|---|---|---|---|
| Drd5 | -6.191965 | -3.230274 | 0.0000000 | 0.0000000 |
| Lratd2 | -4.054375 | -3.133397 | 0.0000503 | 0.0002513 |
| Lct | -3.898989 | -3.115809 | 0.0000966 | 0.0004600 |
| Kcnh7 | -8.710794 | -2.806653 | 0.0000000 | 0.0000000 |
| Bcan | -12.180642 | -2.713535 | 0.0000000 | 0.0000000 |
| Wfs1 | -15.609615 | -2.604273 | 0.0000000 | 0.0000000 |
| Arc | -13.357514 | -2.600173 | 0.0000000 | 0.0000000 |
| Gm2115 | -12.618988 | -2.565489 | 0.0000000 | 0.0000000 |
| Gpr63 | -6.843199 | -2.557320 | 0.0000000 | 0.0000000 |
| Egr4 | -8.029078 | -2.446723 | 0.0000000 | 0.0000000 |
| Lamp5 | -4.905334 | -2.406227 | 0.0000009 | 0.0000053 |
| Epha10 | -7.344985 | -2.288014 | 0.0000000 | 0.0000000 |
| Scn4b | -5.658706 | -2.250183 | 0.0000000 | 0.0000001 |
| Col11a1 | -4.169776 | -2.233136 | 0.0000305 | 0.0001588 |
| Itga7 | -5.319431 | -2.232415 | 0.0000001 | 0.0000007 |
| Gabra1 | -9.056701 | -2.164254 | 0.0000000 | 0.0000000 |
| Epha7 | -10.708636 | -2.157751 | 0.0000000 | 0.0000000 |
| Trib2 | 4.592781 | 2.153502 | 0.0000044 | 0.0000238 |
| Egr2 | -2.749730 | -2.129920 | 0.0059644 | 0.0202872 |
| Col6a1 | 10.558397 | 2.123981 | 0.0000000 | 0.0000000 |
| Neurod6 | -10.620948 | -2.088480 | 0.0000000 | 0.0000000 |
| Nrg2 | -4.106236 | -2.059862 | 0.0000402 | 0.0002052 |
| Plagl1 | 12.469936 | 2.047164 | 0.0000000 | 0.0000000 |
| Kcnd2 | -12.667880 | -2.041409 | 0.0000000 | 0.0000000 |
| Egr1 | -12.270212 | -2.017097 | 0.0000000 | 0.0000000 |
| Htr1a | -8.327378 | -2.003451 | 0.0000000 | 0.0000000 |
| Enpp2 | -3.970348 | -1.972346 | 0.0000718 | 0.0003484 |
| Wnt2 | -3.372658 | -1.919400 | 0.0007445 | 0.0030511 |
| Dkk3 | -11.076118 | -1.886895 | 0.0000000 | 0.0000000 |
| Ndst4 | -3.684617 | -1.776482 | 0.0002290 | 0.0010411 |
| Bcl11b | -10.986549 | -1.757803 | 0.0000000 | 0.0000000 |
| Hs3st1 | -3.228753 | -1.736715 | 0.0012433 | 0.0047455 |
| Hpca | -11.887192 | -1.693197 | 0.0000000 | 0.0000000 |
| Ntsr1 | -2.846129 | -1.673668 | 0.0044254 | 0.0154735 |
| Grp | 6.490464 | 1.666033 | 0.0000000 | 0.0000000 |
| Adgrl2 | -9.457041 | -1.659944 | 0.0000000 | 0.0000000 |
| Lmo1 | -5.903759 | -1.656389 | 0.0000000 | 0.0000000 |
| Nr4a1 | -9.498807 | -1.634760 | 0.0000000 | 0.0000000 |
| Grin2a | -15.506289 | -1.630166 | 0.0000000 | 0.0000000 |
| Meis2 | -4.634052 | -1.617793 | 0.0000036 | 0.0000199 |
| Cckbr | -2.993992 | -1.573156 | 0.0027535 | 0.0099048 |
| Camk2a | -15.047456 | -1.566388 | 0.0000000 | 0.0000000 |
| Npy1r | -2.551193 | -1.559665 | 0.0107355 | 0.0343549 |
| Gpr37 | -3.572779 | -1.553403 | 0.0003532 | 0.0015095 |
| Car4 | -3.364344 | -1.530297 | 0.0007673 | 0.0031189 |
| Hrh3 | 7.125565 | 1.521176 | 0.0000000 | 0.0000000 |
| Pkp2 | -8.441889 | -1.518617 | 0.0000000 | 0.0000000 |
| Nr2f2 | 9.476934 | 1.445323 | 0.0000000 | 0.0000000 |
| Sox8 | -2.703016 | -1.433652 | 0.0068714 | 0.0230582 |
| Tbr1 | -2.569602 | -1.406019 | 0.0101815 | 0.0332730 |
| Kcnab1 | -14.668692 | -1.405700 | 0.0000000 | 0.0000000 |
| Nr4a2 | -9.212976 | -1.399824 | 0.0000000 | 0.0000000 |
| Ctsb | -9.975059 | -1.390653 | 0.0000000 | 0.0000000 |
| Adrb1 | -6.541533 | -1.384369 | 0.0000000 | 0.0000000 |
| Osr1 | 2.776255 | 1.378816 | 0.0054989 | 0.0188319 |
| Fam131a | -14.343471 | -1.359657 | 0.0000000 | 0.0000000 |
| Bcl6 | -9.020180 | -1.350236 | 0.0000000 | 0.0000000 |
| Cx3cl1 | -14.619305 | -1.308419 | 0.0000000 | 0.0000000 |
| Grm1 | -2.915805 | -1.296162 | 0.0035477 | 0.0124920 |
| Crhr1 | -6.547669 | -1.293980 | 0.0000000 | 0.0000000 |
| Plp1 | -9.618266 | -1.258812 | 0.0000000 | 0.0000000 |
| Ptk2b | -14.057443 | -1.256055 | 0.0000000 | 0.0000000 |
| Robo1 | -8.604202 | -1.254897 | 0.0000000 | 0.0000000 |
| Nectin3 | -2.918675 | -1.254360 | 0.0035152 | 0.0124653 |
| Myh11 | 2.730728 | 1.242063 | 0.0063195 | 0.0213496 |
| Gria3 | -10.072248 | -1.234077 | 0.0000000 | 0.0000000 |
| Gria1 | -12.679262 | -1.230100 | 0.0000000 | 0.0000000 |
| Id4 | -3.177882 | -1.219708 | 0.0014836 | 0.0054946 |
| Rbfox3 | -12.419758 | -1.203092 | 0.0000000 | 0.0000000 |
| Plekhg1 | -4.985698 | -1.193509 | 0.0000006 | 0.0000036 |
| Cdh12 | -3.025267 | -1.192861 | 0.0024841 | 0.0090005 |
| Brinp1 | -9.969714 | -1.179770 | 0.0000000 | 0.0000000 |
| Gfap | 7.630815 | 1.176230 | 0.0000000 | 0.0000000 |
| Mapk1 | -5.205019 | -1.173542 | 0.0000002 | 0.0000012 |
| Gpc3 | -2.674611 | -1.152955 | 0.0074816 | 0.0247735 |
| Sorl1 | -10.104910 | -1.133160 | 0.0000000 | 0.0000000 |
| Pdzrn4 | -4.074763 | -1.114685 | 0.0000461 | 0.0002326 |
| Grin2b | -12.796247 | -1.098387 | 0.0000000 | 0.0000000 |
| Adam10 | -4.024287 | -1.093711 | 0.0000571 | 0.0002829 |
| Car12 | -4.311800 | -1.086797 | 0.0000162 | 0.0000861 |
| Gria2 | -10.899653 | -1.074424 | 0.0000000 | 0.0000000 |
| Pcdh9 | -8.576984 | -1.067766 | 0.0000000 | 0.0000000 |
| Prkce | -7.554013 | -1.042431 | 0.0000000 | 0.0000000 |
| Cck | -10.265838 | -1.029759 | 0.0000000 | 0.0000000 |
| Crtac1 | 8.106077 | 1.027262 | 0.0000000 | 0.0000000 |
| Smad3 | -6.919704 | -1.020970 | 0.0000000 | 0.0000000 |
| Tnik | -3.587724 | -1.013020 | 0.0003336 | 0.0014378 |
| Dclk3 | -6.011837 | -1.005108 | 0.0000000 | 0.0000000 |
4.3 CA3 Glut
| names | scores | logfoldchanges | pvals | pvals_adj |
|---|---|---|---|---|
| Sema5b | -9.963718 | -2.998168 | 0.0000000 | 0.0000000 |
| Scn4b | -5.253923 | -2.418384 | 0.0000001 | 0.0000007 |
| Iyd | -6.936011 | -2.402789 | 0.0000000 | 0.0000000 |
| Trib2 | 9.562335 | 2.392363 | 0.0000000 | 0.0000000 |
| Prkcd | -8.414603 | -2.260338 | 0.0000000 | 0.0000000 |
| Car4 | -10.588140 | -2.221318 | 0.0000000 | 0.0000000 |
| Itga7 | -8.698009 | -2.178149 | 0.0000000 | 0.0000000 |
| Npy | 7.757045 | 1.963502 | 0.0000000 | 0.0000000 |
| Cckbr | -6.051846 | -1.935948 | 0.0000000 | 0.0000000 |
| Bcan | -10.321513 | -1.904332 | 0.0000000 | 0.0000000 |
| Neurod6 | -10.836412 | -1.840740 | 0.0000000 | 0.0000000 |
| Ly6g6e | 3.509724 | 1.813584 | 0.0004486 | 0.0016136 |
| Grm2 | 7.685248 | 1.810627 | 0.0000000 | 0.0000000 |
| Npy2r | -14.434289 | -1.653863 | 0.0000000 | 0.0000000 |
| Robo1 | -13.289022 | -1.551422 | 0.0000000 | 0.0000000 |
| Nr4a2 | -8.138291 | -1.494950 | 0.0000000 | 0.0000000 |
| Ntf3 | -2.654873 | -1.478802 | 0.0079338 | 0.0234729 |
| Nectin3 | -8.215781 | -1.472096 | 0.0000000 | 0.0000000 |
| Grp | 7.510216 | 1.436703 | 0.0000000 | 0.0000000 |
| Nos1 | -8.529648 | -1.393604 | 0.0000000 | 0.0000000 |
| Cdh12 | -4.421758 | -1.388731 | 0.0000098 | 0.0000415 |
| Fibcd1 | 8.154010 | 1.388414 | 0.0000000 | 0.0000000 |
| Enpp2 | -5.151538 | -1.367420 | 0.0000003 | 0.0000012 |
| Mmp9 | -2.457155 | -1.357622 | 0.0140042 | 0.0393377 |
| Dcn | -3.888931 | -1.322337 | 0.0001007 | 0.0003933 |
| Id4 | -4.314869 | -1.317898 | 0.0000160 | 0.0000671 |
| Rph3a | -9.515093 | -1.307395 | 0.0000000 | 0.0000000 |
| Crhr1 | -9.526181 | -1.294305 | 0.0000000 | 0.0000000 |
| Plekhg1 | -7.455498 | -1.289077 | 0.0000000 | 0.0000000 |
| Plcxd2 | -5.660659 | -1.284401 | 0.0000000 | 0.0000001 |
| Ngb | -2.922178 | -1.265845 | 0.0034759 | 0.0112127 |
| Cd83 | -2.539063 | -1.262204 | 0.0111150 | 0.0319396 |
| Gpr63 | -4.909085 | -1.249100 | 0.0000009 | 0.0000042 |
| Tcf7l2 | -2.758872 | -1.247907 | 0.0058001 | 0.0179529 |
| Serpina3n | 9.481787 | 1.241485 | 0.0000000 | 0.0000000 |
| Penk | 6.853083 | 1.227823 | 0.0000000 | 0.0000000 |
| Kit | -9.849012 | -1.195954 | 0.0000000 | 0.0000000 |
| Npy1r | -4.045355 | -1.154759 | 0.0000522 | 0.0002073 |
| Camk4 | -12.986540 | -1.153570 | 0.0000000 | 0.0000000 |
| Dclk3 | 6.902831 | 1.146178 | 0.0000000 | 0.0000000 |
| Hs3st1 | -2.995930 | -1.136096 | 0.0027361 | 0.0090003 |
| Egr1 | -8.938679 | -1.132204 | 0.0000000 | 0.0000000 |
| Plxna1 | -12.746381 | -1.129517 | 0.0000000 | 0.0000000 |
| Epha7 | -8.916927 | -1.129469 | 0.0000000 | 0.0000000 |
| Gm2115 | -2.732193 | -1.122267 | 0.0062914 | 0.0192989 |
| Mfsd2a | 5.828553 | 1.104306 | 0.0000000 | 0.0000000 |
| Gfap | 12.501422 | 1.095731 | 0.0000000 | 0.0000000 |
| Dkk3 | -8.220496 | -1.095488 | 0.0000000 | 0.0000000 |
| Cd74 | 2.627344 | 1.072469 | 0.0086054 | 0.0253101 |
| Arc | -6.742881 | -1.072258 | 0.0000000 | 0.0000000 |
| Npnt | 3.079962 | 1.065957 | 0.0020703 | 0.0069942 |
| Esrrg | -2.812529 | -1.049165 | 0.0049154 | 0.0154571 |
| Syndig1l | -2.450783 | -1.020547 | 0.0142546 | 0.0398173 |
| Ntng1 | -3.046867 | -1.014938 | 0.0023124 | 0.0077080 |
| Adrb1 | -4.206749 | -1.007670 | 0.0000259 | 0.0001062 |
| Adamts15 | -3.706550 | -1.007478 | 0.0002101 | 0.0007724 |
| Tbr1 | -3.876993 | -1.006026 | 0.0001058 | 0.0004068 |
4.4 CB Neuron
| names | scores | logfoldchanges | pvals | pvals_adj |
|---|---|---|---|---|
| Fos | -9.153584 | -1.148150 | 0 | 0e+00 |
| Vgf | -5.476257 | -1.059721 | 0 | 5e-07 |
| Nr4a1 | -9.550865 | -1.049225 | 0 | 0e+00 |
4.5 CHOR
| names | scores | logfoldchanges | pvals | pvals_adj |
|---|---|---|---|---|
| Spp1 | 4.606217 | 3.174009 | 0.0000041 | 0.0006834 |
| Ctss | 6.506277 | 2.558002 | 0.0000000 | 0.0000000 |
| Cd74 | 5.074853 | 1.410833 | 0.0000004 | 0.0000969 |
| Vtn | -3.130588 | -1.229544 | 0.0017446 | 0.0459096 |
4.6 DG Glut
| names | scores | logfoldchanges | pvals | pvals_adj |
|---|---|---|---|---|
| Car4 | -5.954676 | -4.612063 | 0.0000000 | 0.0000000 |
| Iyd | -2.888605 | -3.897872 | 0.0038696 | 0.0132519 |
| Crebbp | -3.138983 | -3.448560 | 0.0016954 | 0.0060984 |
| Sema5b | -8.070182 | -3.381921 | 0.0000000 | 0.0000000 |
| Prox1 | -11.451460 | -3.376683 | 0.0000000 | 0.0000000 |
| Col6a1 | 15.069502 | 3.340746 | 0.0000000 | 0.0000000 |
| Pdyn | -7.780768 | -3.314382 | 0.0000000 | 0.0000000 |
| Npy2r | -12.682557 | -3.251736 | 0.0000000 | 0.0000000 |
| Adarb2 | -3.165893 | -3.200292 | 0.0015461 | 0.0056426 |
| Grm1 | -7.125413 | -3.194595 | 0.0000000 | 0.0000000 |
| Itga7 | -9.832137 | -3.168897 | 0.0000000 | 0.0000000 |
| Cdh12 | -4.002225 | -3.060751 | 0.0000627 | 0.0002615 |
| Drd5 | -6.111296 | -3.035839 | 0.0000000 | 0.0000000 |
| Gng2 | -9.008463 | -2.926049 | 0.0000000 | 0.0000000 |
| Cd74 | 4.023231 | 2.919960 | 0.0000574 | 0.0002432 |
| Chrna7 | -9.060155 | -2.903636 | 0.0000000 | 0.0000000 |
| Negr1 | -5.343089 | -2.808587 | 0.0000001 | 0.0000005 |
| Cspg5 | -11.802776 | -2.747140 | 0.0000000 | 0.0000000 |
| Prkce | -16.241940 | -2.742629 | 0.0000000 | 0.0000000 |
| Ntng1 | -6.836531 | -2.740882 | 0.0000000 | 0.0000000 |
| Sox8 | -5.521832 | -2.728541 | 0.0000000 | 0.0000002 |
| Npy1r | -7.011711 | -2.691978 | 0.0000000 | 0.0000000 |
| Rims1 | -9.185610 | -2.669787 | 0.0000000 | 0.0000000 |
| Adrb1 | -6.496010 | -2.666402 | 0.0000000 | 0.0000000 |
| Kcnd2 | -14.632668 | -2.638562 | 0.0000000 | 0.0000000 |
| Epha10 | -8.286418 | -2.610015 | 0.0000000 | 0.0000000 |
| Camk2a | -22.759329 | -2.600446 | 0.0000000 | 0.0000000 |
| Camk2g | -17.222553 | -2.585930 | 0.0000000 | 0.0000000 |
| Cdh9 | -5.595223 | -2.569636 | 0.0000000 | 0.0000001 |
| Gabra1 | -7.970254 | -2.567054 | 0.0000000 | 0.0000000 |
| Mapk1 | -7.810337 | -2.552455 | 0.0000000 | 0.0000000 |
| Lratd2 | -10.576093 | -2.532518 | 0.0000000 | 0.0000000 |
| Egr4 | -3.345221 | -2.521988 | 0.0008222 | 0.0031622 |
| Lct | -12.001356 | -2.498596 | 0.0000000 | 0.0000000 |
| Ctnnb1 | -15.471447 | -2.491804 | 0.0000000 | 0.0000000 |
| Plcg2 | -5.524385 | -2.484487 | 0.0000000 | 0.0000002 |
| Syt17 | -14.850075 | -2.463463 | 0.0000000 | 0.0000000 |
| Nr4a2 | -5.416001 | -2.437834 | 0.0000001 | 0.0000003 |
| Tbr1 | -8.811000 | -2.432638 | 0.0000000 | 0.0000000 |
| Gpc3 | -3.008848 | -2.406959 | 0.0026224 | 0.0091692 |
| Gria2 | -20.482897 | -2.381789 | 0.0000000 | 0.0000000 |
| Nos1 | -7.465934 | -2.368460 | 0.0000000 | 0.0000000 |
| Rasgrf2 | -10.594121 | -2.311158 | 0.0000000 | 0.0000000 |
| Ntng2 | -14.831568 | -2.301035 | 0.0000000 | 0.0000000 |
| Cck | -11.339354 | -2.295702 | 0.0000000 | 0.0000000 |
| Mas1 | -13.068602 | -2.294961 | 0.0000000 | 0.0000000 |
| Ctsb | -11.517192 | -2.286616 | 0.0000000 | 0.0000000 |
| Ntf3 | -4.548292 | -2.199327 | 0.0000054 | 0.0000244 |
| Bcl11b | -14.791788 | -2.170556 | 0.0000000 | 0.0000000 |
| Lamp5 | -3.021612 | -2.160039 | 0.0025143 | 0.0088533 |
| Gpr158 | -11.423912 | -2.128592 | 0.0000000 | 0.0000000 |
| Sorl1 | -15.302543 | -2.111150 | 0.0000000 | 0.0000000 |
| Kctd4 | -7.967329 | -2.090750 | 0.0000000 | 0.0000000 |
| Nrg2 | -12.488551 | -2.050165 | 0.0000000 | 0.0000000 |
| Smad3 | -15.523778 | -2.040720 | 0.0000000 | 0.0000000 |
| Cpne6 | -21.323004 | -2.017199 | 0.0000000 | 0.0000000 |
| Cacng5 | -2.553455 | -1.999802 | 0.0106660 | 0.0346299 |
| Nr2f2 | 4.261006 | 1.981966 | 0.0000204 | 0.0000900 |
| Ptk2b | -23.221050 | -1.943977 | 0.0000000 | 0.0000000 |
| Tnik | -4.131775 | -1.921604 | 0.0000360 | 0.0001552 |
| Myo5a | -9.692004 | -1.905438 | 0.0000000 | 0.0000000 |
| Rph3a | -18.126266 | -1.885537 | 0.0000000 | 0.0000000 |
| Gria1 | -20.174604 | -1.856521 | 0.0000000 | 0.0000000 |
| Fam131a | -20.078930 | -1.853892 | 0.0000000 | 0.0000000 |
| Csf1 | -8.562962 | -1.836201 | 0.0000000 | 0.0000000 |
| Synpr | -2.511388 | -1.830895 | 0.0120257 | 0.0385440 |
| Ndst4 | -3.085163 | -1.820293 | 0.0020344 | 0.0072657 |
| Vgf | 12.380434 | 1.812606 | 0.0000000 | 0.0000000 |
| Grin2a | -18.679565 | -1.804108 | 0.0000000 | 0.0000000 |
| Syp | -20.636219 | -1.792395 | 0.0000000 | 0.0000000 |
| Lrpprc | -7.629042 | -1.779802 | 0.0000000 | 0.0000000 |
| Kcnc1 | -14.058948 | -1.775951 | 0.0000000 | 0.0000000 |
| Lmo1 | -5.532681 | -1.772336 | 0.0000000 | 0.0000002 |
| Ctss | 4.988901 | 1.747297 | 0.0000006 | 0.0000029 |
| Pcdhgc5 | -14.246465 | -1.741296 | 0.0000000 | 0.0000000 |
| Ngrn | -3.153555 | -1.720106 | 0.0016129 | 0.0058440 |
| Gpr37 | -3.770673 | -1.713156 | 0.0001628 | 0.0006672 |
| Car12 | -9.476565 | -1.705796 | 0.0000000 | 0.0000000 |
| Pkp2 | -8.785366 | -1.700253 | 0.0000000 | 0.0000000 |
| Cx3cl1 | -17.965391 | -1.698011 | 0.0000000 | 0.0000000 |
| Bcan | -3.362026 | -1.681482 | 0.0007737 | 0.0029989 |
| Eno2 | -17.855467 | -1.676016 | 0.0000000 | 0.0000000 |
| Sox10 | 3.197749 | 1.653551 | 0.0013850 | 0.0051681 |
| Hpca | -17.464636 | -1.642875 | 0.0000000 | 0.0000000 |
| Npnt | -9.217944 | -1.608085 | 0.0000000 | 0.0000000 |
| Stard8 | -4.100930 | -1.606739 | 0.0000411 | 0.0001759 |
| Ntrk2 | -3.773757 | -1.592374 | 0.0001608 | 0.0006645 |
| Dapk1 | -13.117635 | -1.588032 | 0.0000000 | 0.0000000 |
| Htr1a | -5.205083 | -1.570749 | 0.0000002 | 0.0000010 |
| Pcdh9 | -12.586990 | -1.565680 | 0.0000000 | 0.0000000 |
| Neto1 | -9.151893 | -1.556741 | 0.0000000 | 0.0000000 |
| Bace1 | -3.078888 | -1.522918 | 0.0020777 | 0.0073679 |
| Npy | 2.414386 | 1.495330 | 0.0157618 | 0.0495653 |
| Fibcd1 | -5.910163 | -1.448798 | 0.0000000 | 0.0000000 |
| Sstr3 | -3.250877 | -1.438732 | 0.0011505 | 0.0043579 |
| Psen2 | -4.228139 | -1.432190 | 0.0000236 | 0.0001033 |
| Adam10 | -3.641654 | -1.424411 | 0.0002709 | 0.0010582 |
| Grm3 | -3.724617 | -1.418961 | 0.0001956 | 0.0007824 |
| Robo1 | -5.001026 | -1.407868 | 0.0000006 | 0.0000027 |
| Slc17a7 | -16.818161 | -1.402455 | 0.0000000 | 0.0000000 |
| Bin1 | -14.892460 | -1.401940 | 0.0000000 | 0.0000000 |
| Grb2 | -8.933210 | -1.398963 | 0.0000000 | 0.0000000 |
| Tmem150a | -4.775696 | -1.375869 | 0.0000018 | 0.0000084 |
| Gad1 | -7.662386 | -1.374605 | 0.0000000 | 0.0000000 |
| Psen1 | -6.392944 | -1.371679 | 0.0000000 | 0.0000000 |
| Slc29a1 | -5.192851 | -1.365064 | 0.0000002 | 0.0000010 |
| Mink1 | -15.699117 | -1.352942 | 0.0000000 | 0.0000000 |
| Pcdhgc3 | -4.684437 | -1.324283 | 0.0000028 | 0.0000130 |
| Src | -12.334910 | -1.300029 | 0.0000000 | 0.0000000 |
| Gria3 | -10.233817 | -1.297208 | 0.0000000 | 0.0000000 |
| Map4k3 | -4.719217 | -1.295583 | 0.0000024 | 0.0000111 |
| Pdgfa | -7.075901 | -1.294499 | 0.0000000 | 0.0000000 |
| Fermt2 | -3.209395 | -1.291492 | 0.0013301 | 0.0050005 |
| Bcl6 | -9.176941 | -1.289376 | 0.0000000 | 0.0000000 |
| Grm2 | -11.933922 | -1.246578 | 0.0000000 | 0.0000000 |
| Gfap | 8.050611 | 1.215875 | 0.0000000 | 0.0000000 |
| Epha7 | -11.008564 | -1.179198 | 0.0000000 | 0.0000000 |
| Nptx1 | -15.579086 | -1.169732 | 0.0000000 | 0.0000000 |
| Slc29a2 | -2.533299 | -1.115754 | 0.0112994 | 0.0364498 |
| Pcdhac2 | -5.335271 | -1.081160 | 0.0000001 | 0.0000005 |
| Grin2b | -13.881853 | -1.062299 | 0.0000000 | 0.0000000 |
| Rbfox3 | -13.661894 | -1.057280 | 0.0000000 | 0.0000000 |
| Gphn | -6.575463 | -1.003536 | 0.0000000 | 0.0000000 |
| Plp1 | -6.687304 | -1.002527 | 0.0000000 | 0.0000000 |
4.7 Endothelial
| names | scores | logfoldchanges | pvals | pvals_adj |
|---|---|---|---|---|
| Cd74 | 9.577570 | 2.585067 | 0.0000000 | 0.0000000 |
| Serpina3n | 3.748965 | 1.962930 | 0.0001776 | 0.0012683 |
| C4b | 5.126868 | 1.218350 | 0.0000003 | 0.0000031 |
| Fos | -3.957550 | -1.149680 | 0.0000757 | 0.0005651 |
| Gfap | 18.504066 | 1.106034 | 0.0000000 | 0.0000000 |
| Synpo2 | -10.172818 | -1.001326 | 0.0000000 | 0.0000000 |
4.8 L2_3 IT Glut
| names | scores | logfoldchanges | pvals | pvals_adj |
|---|---|---|---|---|
| Fibcd1 | -8.174534 | -2.622705 | 0.0000000 | 0.0000000 |
| Ndnf | -2.873666 | -1.840048 | 0.0040574 | 0.0099446 |
| Egr4 | -20.676815 | -1.770479 | 0.0000000 | 0.0000000 |
| Egr2 | -15.297562 | -1.753064 | 0.0000000 | 0.0000000 |
| Fos | -22.158278 | -1.699495 | 0.0000000 | 0.0000000 |
| Fosl2 | -22.131536 | -1.695000 | 0.0000000 | 0.0000000 |
| Car4 | -13.500947 | -1.679523 | 0.0000000 | 0.0000000 |
| Fosb | -14.063915 | -1.626696 | 0.0000000 | 0.0000000 |
| Nr4a2 | -11.575624 | -1.533527 | 0.0000000 | 0.0000000 |
| Adrb1 | -29.606792 | -1.473771 | 0.0000000 | 0.0000000 |
| Egr1 | -34.335995 | -1.441938 | 0.0000000 | 0.0000000 |
| Nr4a1 | -30.301668 | -1.434474 | 0.0000000 | 0.0000000 |
| Sema5b | -9.691622 | -1.390324 | 0.0000000 | 0.0000000 |
| Npnt | -13.856658 | -1.354121 | 0.0000000 | 0.0000000 |
| Cspg5 | -28.605438 | -1.347954 | 0.0000000 | 0.0000000 |
| Cd74 | 6.349783 | 1.346901 | 0.0000000 | 0.0000000 |
| Ptpru | -13.878231 | -1.325718 | 0.0000000 | 0.0000000 |
| Crhr1 | -29.079260 | -1.278748 | 0.0000000 | 0.0000000 |
| Mgp | -3.036500 | -1.232444 | 0.0023934 | 0.0060440 |
| Scn4b | -13.329892 | -1.229025 | 0.0000000 | 0.0000000 |
| Nectin3 | -15.859935 | -1.226602 | 0.0000000 | 0.0000000 |
| Rph3a | -30.927746 | -1.216501 | 0.0000000 | 0.0000000 |
| Fezf2 | -2.943514 | -1.213592 | 0.0032451 | 0.0080324 |
| Lamp5 | -25.432514 | -1.201549 | 0.0000000 | 0.0000000 |
| Cx3cl1 | -37.528553 | -1.180060 | 0.0000000 | 0.0000000 |
| Camk4 | -31.443071 | -1.172730 | 0.0000000 | 0.0000000 |
| Jam2 | -2.697098 | -1.157315 | 0.0069947 | 0.0168953 |
| Apoe | -29.598629 | -1.145100 | 0.0000000 | 0.0000000 |
| Bcan | -13.610049 | -1.139868 | 0.0000000 | 0.0000000 |
| Otof | -14.906362 | -1.130868 | 0.0000000 | 0.0000000 |
| Ppp1r1b | 28.204140 | 1.130331 | 0.0000000 | 0.0000000 |
| Grm2 | -20.895922 | -1.124576 | 0.0000000 | 0.0000000 |
| Ngb | -4.389131 | -1.111987 | 0.0000114 | 0.0000343 |
| Ddit4l | -3.705112 | -1.105471 | 0.0002113 | 0.0005869 |
| Lrrc55 | -15.108859 | -1.103727 | 0.0000000 | 0.0000000 |
| Grp | -3.910503 | -1.098897 | 0.0000921 | 0.0002647 |
| Stard8 | -22.458380 | -1.093667 | 0.0000000 | 0.0000000 |
| Sox8 | -13.469996 | -1.089075 | 0.0000000 | 0.0000000 |
| Gfap | 20.074620 | 1.086906 | 0.0000000 | 0.0000000 |
| Mas1 | -17.865356 | -1.086671 | 0.0000000 | 0.0000000 |
| Penk | -13.268831 | -1.064893 | 0.0000000 | 0.0000000 |
| Rspo1 | -5.410357 | -1.062304 | 0.0000001 | 0.0000002 |
| Lratd2 | -3.000570 | -1.048828 | 0.0026948 | 0.0067369 |
| Oxgr1 | -4.946007 | -1.038561 | 0.0000008 | 0.0000025 |
4.9 L4_5 IT Glut
| names | scores | logfoldchanges | pvals | pvals_adj |
|---|---|---|---|---|
| Cd74 | 13.180964 | 3.145334 | 0.0000000 | 0.0000000 |
| Egr2 | -15.693312 | -1.763540 | 0.0000000 | 0.0000000 |
| Cxcl10 | 3.319119 | 1.525908 | 0.0009030 | 0.0029705 |
| Egr4 | -18.764074 | -1.518028 | 0.0000000 | 0.0000000 |
| Fosb | -13.508392 | -1.514867 | 0.0000000 | 0.0000000 |
| Bcan | -14.650078 | -1.369449 | 0.0000000 | 0.0000000 |
| Gfap | 20.850578 | 1.327615 | 0.0000000 | 0.0000000 |
| Igf2 | -4.037504 | -1.297898 | 0.0000540 | 0.0001957 |
| Cspg5 | -30.988180 | -1.239828 | 0.0000000 | 0.0000000 |
| Serpina3n | 4.594737 | 1.233951 | 0.0000043 | 0.0000179 |
| Fos | -22.736520 | -1.230804 | 0.0000000 | 0.0000000 |
| Adrb1 | -22.953900 | -1.183014 | 0.0000000 | 0.0000000 |
| Clec7a | 2.514453 | 1.172788 | 0.0119217 | 0.0331159 |
| Sst | -13.747972 | -1.168542 | 0.0000000 | 0.0000000 |
| Scn4b | -16.260290 | -1.160662 | 0.0000000 | 0.0000000 |
| Sox8 | -10.863413 | -1.155441 | 0.0000000 | 0.0000000 |
| Fosl2 | -14.978842 | -1.137228 | 0.0000000 | 0.0000000 |
| Htr1a | -8.065847 | -1.121700 | 0.0000000 | 0.0000000 |
| Apoe | -29.738697 | -1.105550 | 0.0000000 | 0.0000000 |
| Rph3a | -34.846806 | -1.077260 | 0.0000000 | 0.0000000 |
| C4b | 3.144409 | 1.023812 | 0.0016642 | 0.0053001 |
| Egr1 | -30.680056 | -1.013146 | 0.0000000 | 0.0000000 |
| Grm4 | -15.561079 | -1.009871 | 0.0000000 | 0.0000000 |
4.10 L5 ET Glut
| names | scores | logfoldchanges | pvals | pvals_adj |
|---|---|---|---|---|
| Cd74 | 6.588143 | 3.480968 | 0.0000000 | 0.0000000 |
| Egr2 | -3.961940 | -1.917788 | 0.0000743 | 0.0003442 |
| Egr4 | -11.947008 | -1.740308 | 0.0000000 | 0.0000000 |
| Fosb | -5.537108 | -1.479007 | 0.0000000 | 0.0000002 |
| Htr1a | -3.608506 | -1.420444 | 0.0003080 | 0.0013049 |
| Sst | -10.027505 | -1.412893 | 0.0000000 | 0.0000000 |
| Cspg5 | -13.398189 | -1.326896 | 0.0000000 | 0.0000000 |
| Pcdh11x | -3.852487 | -1.260020 | 0.0001169 | 0.0005220 |
| Egr1 | -13.578428 | -1.251176 | 0.0000000 | 0.0000000 |
| Adrb1 | -10.681449 | -1.250625 | 0.0000000 | 0.0000000 |
| Fos | -8.049476 | -1.181501 | 0.0000000 | 0.0000000 |
| Gfap | 7.423714 | 1.173134 | 0.0000000 | 0.0000000 |
| Lrrc55 | -2.823252 | -1.159461 | 0.0047539 | 0.0178719 |
| Apoe | -13.366623 | -1.092326 | 0.0000000 | 0.0000000 |
| Tpbg | -3.125981 | -1.067182 | 0.0017721 | 0.0070323 |
| Nr4a2 | -4.620321 | -1.047722 | 0.0000038 | 0.0000202 |
| Enpp2 | -6.522738 | -1.047069 | 0.0000000 | 0.0000000 |
| Ntsr1 | -2.649393 | -1.033771 | 0.0080637 | 0.0289913 |
| Cx3cl1 | -13.574212 | -1.022074 | 0.0000000 | 0.0000000 |
| Kcnab1 | -10.200034 | -1.016279 | 0.0000000 | 0.0000000 |
4.11 L6 CT Glut
| names | scores | logfoldchanges | pvals | pvals_adj |
|---|---|---|---|---|
| Cd74 | 11.045413 | 3.828277 | 0.0000000 | 0.0000000 |
| Egr2 | -11.265487 | -2.128186 | 0.0000000 | 0.0000000 |
| Egr4 | -12.481452 | -1.869583 | 0.0000000 | 0.0000000 |
| Fos | -20.459060 | -1.783920 | 0.0000000 | 0.0000000 |
| Fosb | -6.778194 | -1.690296 | 0.0000000 | 0.0000000 |
| Grp | -7.681380 | -1.651657 | 0.0000000 | 0.0000000 |
| Sema5b | -16.287370 | -1.626038 | 0.0000000 | 0.0000000 |
| Htr1a | -7.330582 | -1.623997 | 0.0000000 | 0.0000000 |
| Fosl2 | -10.674314 | -1.614164 | 0.0000000 | 0.0000000 |
| Nr4a1 | -29.766352 | -1.520325 | 0.0000000 | 0.0000000 |
| Sox8 | -17.210140 | -1.443844 | 0.0000000 | 0.0000000 |
| Egr1 | -28.885315 | -1.207918 | 0.0000000 | 0.0000000 |
| Nr4a2 | -10.304528 | -1.198852 | 0.0000000 | 0.0000000 |
| Cspg5 | -20.882948 | -1.180324 | 0.0000000 | 0.0000000 |
| Cxcl10 | 2.554330 | 1.151787 | 0.0106393 | 0.0366871 |
| Serpina3n | 3.353295 | 1.132084 | 0.0007986 | 0.0032462 |
| Cx3cl1 | -29.568316 | -1.033014 | 0.0000000 | 0.0000000 |
| Adrb1 | -12.748731 | -1.032174 | 0.0000000 | 0.0000000 |
4.12 L6 IT Glut
| names | scores | logfoldchanges | pvals | pvals_adj |
|---|---|---|---|---|
| Cd74 | 6.659259 | 2.557009 | 0.0000000 | 0.0000000 |
| Fosl2 | -15.437291 | -1.801963 | 0.0000000 | 0.0000000 |
| Egr2 | -5.813492 | -1.614173 | 0.0000000 | 0.0000000 |
| Penk | -15.342633 | -1.560274 | 0.0000000 | 0.0000000 |
| Fosb | -8.443142 | -1.501059 | 0.0000000 | 0.0000000 |
| Egr4 | -10.693886 | -1.475045 | 0.0000000 | 0.0000000 |
| Ptpru | -22.552866 | -1.448234 | 0.0000000 | 0.0000000 |
| Sox8 | -15.520917 | -1.412241 | 0.0000000 | 0.0000000 |
| Adrb1 | -20.434456 | -1.394861 | 0.0000000 | 0.0000000 |
| Htr1a | -9.371473 | -1.351679 | 0.0000000 | 0.0000000 |
| Egr1 | -25.639118 | -1.316748 | 0.0000000 | 0.0000000 |
| Fos | -12.646792 | -1.305286 | 0.0000000 | 0.0000000 |
| Cspg5 | -22.620780 | -1.282444 | 0.0000000 | 0.0000000 |
| Tpbg | -5.211852 | -1.262050 | 0.0000002 | 0.0000007 |
| Mog | -5.298135 | -1.234448 | 0.0000001 | 0.0000005 |
| Stard8 | -10.588483 | -1.231473 | 0.0000000 | 0.0000000 |
| Nr4a1 | -20.973999 | -1.228160 | 0.0000000 | 0.0000000 |
| Cldn11 | -6.247221 | -1.204305 | 0.0000000 | 0.0000000 |
| Syt6 | 7.852458 | 1.193932 | 0.0000000 | 0.0000000 |
| Sema5b | -16.887383 | -1.185215 | 0.0000000 | 0.0000000 |
| Crhr1 | -18.822767 | -1.138837 | 0.0000000 | 0.0000000 |
| Cckbr | -21.306192 | -1.120681 | 0.0000000 | 0.0000000 |
| Enpp2 | -13.248084 | -1.111644 | 0.0000000 | 0.0000000 |
| Cx3cl1 | -26.957289 | -1.095771 | 0.0000000 | 0.0000000 |
| Rph3a | -23.197723 | -1.056088 | 0.0000000 | 0.0000000 |
| Mas1 | -11.243724 | -1.014174 | 0.0000000 | 0.0000000 |
| Cxcr4 | 3.077891 | 1.004127 | 0.0020847 | 0.0061678 |
4.13 L6b Glut
| names | scores | logfoldchanges | pvals | pvals_adj |
|---|---|---|---|---|
| Cd74 | 5.714800 | 4.052389 | 0.0000000 | 0.0000001 |
| Grp | -4.308826 | -1.418620 | 0.0000164 | 0.0001039 |
| Bcan | -5.311912 | -1.229256 | 0.0000001 | 0.0000010 |
| Cspg5 | -11.514272 | -1.153825 | 0.0000000 | 0.0000000 |
| Adrb1 | -5.293157 | -1.058681 | 0.0000001 | 0.0000011 |
| Lamp5 | -3.121837 | -1.057681 | 0.0017973 | 0.0097677 |
| Tpbg | -7.130207 | -1.042298 | 0.0000000 | 0.0000000 |
| Egr1 | -10.115523 | -1.035635 | 0.0000000 | 0.0000000 |
| Cx3cl1 | -15.160847 | -1.002740 | 0.0000000 | 0.0000000 |
4.14 Microglia
| names | scores | logfoldchanges | pvals | pvals_adj |
|---|---|---|---|---|
| Cd74 | 63.946007 | 4.973553 | 0.0000000 | 0.0000000 |
| Cst7 | 24.697985 | 4.365547 | 0.0000000 | 0.0000000 |
| C3 | 29.547565 | 4.028767 | 0.0000000 | 0.0000000 |
| Cxcl10 | 8.001764 | 3.791353 | 0.0000000 | 0.0000000 |
| Itgal | 22.626020 | 3.734685 | 0.0000000 | 0.0000000 |
| Lgals3 | 20.181517 | 3.703766 | 0.0000000 | 0.0000000 |
| Spp1 | 21.749884 | 3.572593 | 0.0000000 | 0.0000000 |
| Clec7a | 16.080172 | 3.559483 | 0.0000000 | 0.0000000 |
| C4b | 37.264393 | 3.310130 | 0.0000000 | 0.0000000 |
| Itgax | 25.150688 | 2.782841 | 0.0000000 | 0.0000000 |
| Xdh | 21.722470 | 2.764679 | 0.0000000 | 0.0000000 |
| Serpina3n | 8.792327 | 2.612850 | 0.0000000 | 0.0000000 |
| Tmem119 | -54.498180 | -2.413195 | 0.0000000 | 0.0000000 |
| Cx3cr1 | -55.075550 | -2.339749 | 0.0000000 | 0.0000000 |
| Gpc3 | 17.427013 | 2.171520 | 0.0000000 | 0.0000000 |
| Cxcr4 | 6.154465 | 2.126732 | 0.0000000 | 0.0000000 |
| Anpep | 3.850223 | 2.110441 | 0.0001180 | 0.0003334 |
| Cxcl2 | 13.279420 | 2.108510 | 0.0000000 | 0.0000000 |
| Cd8a | 5.297342 | 2.096031 | 0.0000001 | 0.0000004 |
| Selplg | -52.013844 | -2.039347 | 0.0000000 | 0.0000000 |
| Hpca | -22.053387 | -1.969876 | 0.0000000 | 0.0000000 |
| Neu4 | 8.290473 | 1.952566 | 0.0000000 | 0.0000000 |
| P2ry12 | -34.855510 | -1.926756 | 0.0000000 | 0.0000000 |
| Egr4 | -3.697687 | -1.902346 | 0.0002176 | 0.0005977 |
| Rph3a | -26.152880 | -1.892608 | 0.0000000 | 0.0000000 |
| Siglech | -40.673912 | -1.855954 | 0.0000000 | 0.0000000 |
| Cd4 | 3.901264 | 1.807051 | 0.0000957 | 0.0002734 |
| Syp | -27.992123 | -1.803238 | 0.0000000 | 0.0000000 |
| Gjb1 | -5.976529 | -1.786283 | 0.0000000 | 0.0000000 |
| Bcan | -16.760900 | -1.758267 | 0.0000000 | 0.0000000 |
| Grin2c | -4.877934 | -1.752813 | 0.0000011 | 0.0000034 |
| Adrb1 | -15.016638 | -1.710413 | 0.0000000 | 0.0000000 |
| Mog | -7.923509 | -1.710356 | 0.0000000 | 0.0000000 |
| Fmo1 | 7.542876 | 1.706857 | 0.0000000 | 0.0000000 |
| Lpl | 4.196773 | 1.696768 | 0.0000271 | 0.0000796 |
| Lcn2 | 2.791243 | 1.696106 | 0.0052506 | 0.0119877 |
| Ddit3 | 22.460218 | 1.688921 | 0.0000000 | 0.0000000 |
| Csf1r | -47.201733 | -1.687757 | 0.0000000 | 0.0000000 |
| Cspg5 | -15.670618 | -1.681289 | 0.0000000 | 0.0000000 |
| Gm2115 | -3.509078 | -1.680019 | 0.0004497 | 0.0011649 |
| Cplx1 | -29.083132 | -1.675126 | 0.0000000 | 0.0000000 |
| Camk2a | -28.531832 | -1.670738 | 0.0000000 | 0.0000000 |
| Grin2b | -13.318376 | -1.661097 | 0.0000000 | 0.0000000 |
| Scn4b | -10.303435 | -1.623348 | 0.0000000 | 0.0000000 |
| Opalin | -3.478325 | -1.607014 | 0.0005046 | 0.0013004 |
| Apoc1 | 2.682868 | 1.605342 | 0.0072994 | 0.0160779 |
| Htr5a | -2.313667 | -1.601304 | 0.0206860 | 0.0425638 |
| Syn1 | -21.841890 | -1.597705 | 0.0000000 | 0.0000000 |
| Ly9 | 23.592302 | 1.596093 | 0.0000000 | 0.0000000 |
| Neto1 | -7.016478 | -1.586585 | 0.0000000 | 0.0000000 |
| Nefm | -18.520222 | -1.584442 | 0.0000000 | 0.0000000 |
| Fam131a | -19.516308 | -1.580831 | 0.0000000 | 0.0000000 |
| Id4 | -7.511149 | -1.577027 | 0.0000000 | 0.0000000 |
| Kcnab1 | -11.773004 | -1.574934 | 0.0000000 | 0.0000000 |
| Dlg4 | -33.241410 | -1.527379 | 0.0000000 | 0.0000000 |
| Dnm1 | -22.177908 | -1.526562 | 0.0000000 | 0.0000000 |
| Csf1 | 19.762161 | 1.511753 | 0.0000000 | 0.0000000 |
| Slc32a1 | -9.173188 | -1.511452 | 0.0000000 | 0.0000000 |
| Ppp1r3g | -2.459668 | -1.509429 | 0.0139065 | 0.0297148 |
| Tnf | 7.599371 | 1.509385 | 0.0000000 | 0.0000000 |
| Eno2 | -23.115350 | -1.505098 | 0.0000000 | 0.0000000 |
| Agt | -7.149469 | -1.494736 | 0.0000000 | 0.0000000 |
| Tpbg | -2.783541 | -1.484553 | 0.0053769 | 0.0122203 |
| Sox8 | -7.911628 | -1.481774 | 0.0000000 | 0.0000000 |
| Slc7a10 | -4.916309 | -1.464087 | 0.0000009 | 0.0000028 |
| Grin1 | -19.321404 | -1.462685 | 0.0000000 | 0.0000000 |
| Mapt | -21.850910 | -1.456870 | 0.0000000 | 0.0000000 |
| Grin2a | -11.462131 | -1.451628 | 0.0000000 | 0.0000000 |
| S100b | -13.454475 | -1.440448 | 0.0000000 | 0.0000000 |
| Cxcl14 | -7.527935 | -1.438474 | 0.0000000 | 0.0000000 |
| Gabra1 | -6.405670 | -1.436034 | 0.0000000 | 0.0000000 |
| Dkk3 | -13.380318 | -1.415208 | 0.0000000 | 0.0000000 |
| Foxp2 | -2.643956 | -1.413301 | 0.0081943 | 0.0179700 |
| Grm2 | -3.341079 | -1.393014 | 0.0008345 | 0.0020454 |
| Atf3 | 11.670850 | 1.390785 | 0.0000000 | 0.0000000 |
| Negr1 | -3.382149 | -1.388690 | 0.0007192 | 0.0017980 |
| Grm3 | -12.670980 | -1.384276 | 0.0000000 | 0.0000000 |
| Lamp5 | -4.626317 | -1.378511 | 0.0000037 | 0.0000113 |
| Grm4 | -3.739117 | -1.378497 | 0.0001847 | 0.0005130 |
| Cd14 | -20.866608 | -1.378410 | 0.0000000 | 0.0000000 |
| Six3 | -3.582945 | -1.376206 | 0.0003397 | 0.0008988 |
| Meis2 | -8.014439 | -1.374740 | 0.0000000 | 0.0000000 |
| Pcdh9 | -12.228945 | -1.370368 | 0.0000000 | 0.0000000 |
| Rgs5 | -3.580261 | -1.361154 | 0.0003433 | 0.0009033 |
| Syngap1 | -20.967163 | -1.357107 | 0.0000000 | 0.0000000 |
| Rbfox3 | -15.165191 | -1.348417 | 0.0000000 | 0.0000000 |
| Gria2 | -13.748306 | -1.348030 | 0.0000000 | 0.0000000 |
| Mfsd2a | -3.649040 | -1.346155 | 0.0002632 | 0.0007076 |
| Epha10 | -2.637206 | -1.335845 | 0.0083592 | 0.0182515 |
| Penk | -7.827449 | -1.334967 | 0.0000000 | 0.0000000 |
| Ecscr | -13.241029 | -1.331579 | 0.0000000 | 0.0000000 |
| Rgs12 | 15.605325 | 1.330034 | 0.0000000 | 0.0000000 |
| Gpr37 | -4.209537 | -1.326365 | 0.0000256 | 0.0000757 |
| Cckbr | -3.652627 | -1.323199 | 0.0002596 | 0.0007015 |
| Rasgrf2 | -4.842848 | -1.322461 | 0.0000013 | 0.0000040 |
| Bin1 | -37.857285 | -1.315697 | 0.0000000 | 0.0000000 |
| Elfn1 | -3.730522 | -1.308409 | 0.0001911 | 0.0005279 |
| Kcnd2 | -6.114942 | -1.302207 | 0.0000000 | 0.0000000 |
| Lrrc55 | -2.425841 | -1.292904 | 0.0152730 | 0.0323580 |
| Syt17 | -2.455358 | -1.286476 | 0.0140744 | 0.0299456 |
| Nrg3 | -5.688522 | -1.282046 | 0.0000000 | 0.0000000 |
| Cldn11 | -5.734639 | -1.281896 | 0.0000000 | 0.0000000 |
| Ppp1r1b | -13.126994 | -1.276925 | 0.0000000 | 0.0000000 |
| Syndig1l | -6.604495 | -1.274800 | 0.0000000 | 0.0000000 |
| Gria1 | -13.958590 | -1.268362 | 0.0000000 | 0.0000000 |
| Nptxr | -13.889064 | -1.262523 | 0.0000000 | 0.0000000 |
| Vgf | -12.293935 | -1.258393 | 0.0000000 | 0.0000000 |
| Cpne5 | -5.260164 | -1.241260 | 0.0000001 | 0.0000005 |
| Enpp2 | -6.956770 | -1.240104 | 0.0000000 | 0.0000000 |
| Olig1 | -10.634375 | -1.236012 | 0.0000000 | 0.0000000 |
| Gpr158 | -6.361823 | -1.231967 | 0.0000000 | 0.0000000 |
| Camk4 | -10.088779 | -1.231667 | 0.0000000 | 0.0000000 |
| Trem2 | -34.723385 | -1.228153 | 0.0000000 | 0.0000000 |
| Gria4 | -4.943034 | -1.218861 | 0.0000008 | 0.0000025 |
| Lynx1 | -15.970130 | -1.214346 | 0.0000000 | 0.0000000 |
| Rorb | -5.016793 | -1.211188 | 0.0000005 | 0.0000017 |
| Rims2 | -6.495607 | -1.205873 | 0.0000000 | 0.0000000 |
| Robo1 | -7.861152 | -1.190639 | 0.0000000 | 0.0000000 |
| Erbb4 | -2.753368 | -1.188461 | 0.0058986 | 0.0133451 |
| Dclk3 | -7.753090 | -1.175498 | 0.0000000 | 0.0000000 |
| Prkce | -6.479829 | -1.164746 | 0.0000000 | 0.0000000 |
| Epha7 | -3.753278 | -1.164692 | 0.0001745 | 0.0004875 |
| Cd83 | 12.759947 | 1.162782 | 0.0000000 | 0.0000000 |
| Drd2 | -2.418683 | -1.156987 | 0.0155768 | 0.0327244 |
| Itga7 | -2.342017 | -1.146786 | 0.0191799 | 0.0396278 |
| Cbs | -3.463257 | -1.146054 | 0.0005337 | 0.0013614 |
| Myl9 | -2.366356 | -1.145835 | 0.0179641 | 0.0374253 |
| Sst | -6.153507 | -1.141457 | 0.0000000 | 0.0000000 |
| Apoe | 26.440660 | 1.140031 | 0.0000000 | 0.0000000 |
| Serpinf1 | -5.001376 | -1.128805 | 0.0000006 | 0.0000018 |
| Gad2 | -6.844688 | -1.128761 | 0.0000000 | 0.0000000 |
| Brinp1 | -8.307802 | -1.126785 | 0.0000000 | 0.0000000 |
| App | -31.694534 | -1.118341 | 0.0000000 | 0.0000000 |
| Rims1 | -5.009360 | -1.117869 | 0.0000005 | 0.0000018 |
| Slc30a3 | -4.545061 | -1.117339 | 0.0000055 | 0.0000166 |
| Gja1 | -9.814078 | -1.110382 | 0.0000000 | 0.0000000 |
| Abi3 | -28.741728 | -1.104618 | 0.0000000 | 0.0000000 |
| Pvalb | -3.606583 | -1.101951 | 0.0003103 | 0.0008296 |
| Cck | -7.808821 | -1.096803 | 0.0000000 | 0.0000000 |
| Slc17a7 | -12.869619 | -1.090657 | 0.0000000 | 0.0000000 |
| Gad1 | -6.309830 | -1.090095 | 0.0000000 | 0.0000000 |
| Pdgfrb | 10.181975 | 1.087649 | 0.0000000 | 0.0000000 |
| Cx3cl1 | -12.226503 | -1.080976 | 0.0000000 | 0.0000000 |
| Nptx2 | -3.165335 | -1.080356 | 0.0015490 | 0.0036534 |
| Chrm4 | -2.562861 | -1.075552 | 0.0103814 | 0.0225682 |
| Spi1 | -16.132265 | -1.073453 | 0.0000000 | 0.0000000 |
| Pcdhac2 | -4.466461 | -1.060731 | 0.0000080 | 0.0000240 |
| Flt1 | -3.773511 | -1.048025 | 0.0001610 | 0.0004522 |
| Cnr1 | -3.087397 | -1.028985 | 0.0020192 | 0.0046740 |
| Ntrk2 | -5.276340 | -1.026675 | 0.0000001 | 0.0000004 |
| Hs3st1 | -3.338516 | -1.024509 | 0.0008423 | 0.0020543 |
| Arc | -12.419890 | -1.007726 | 0.0000000 | 0.0000000 |
4.15 MY_MB_P_HY Neuron
| names | scores | logfoldchanges | pvals | pvals_adj |
|---|---|---|---|---|
| Car4 | -4.436538 | -1.380672 | 9.1e-06 | 2.1e-05 |
| Adarb2 | -8.519075 | -1.119324 | 0.0e+00 | 0.0e+00 |
| Trhr | -5.851647 | -1.103519 | 0.0e+00 | 0.0e+00 |
| Npy1r | -7.593289 | -1.039569 | 0.0e+00 | 0.0e+00 |
| Mapk1 | -18.737139 | -1.038007 | 0.0e+00 | 0.0e+00 |
| Bmp2 | -5.488219 | -1.031323 | 0.0e+00 | 1.0e-07 |
| Gabra1 | -29.626926 | -1.020203 | 0.0e+00 | 0.0e+00 |
| Ndnf | -5.255598 | -1.003972 | 1.0e-07 | 4.0e-07 |
4.16 Oligo
| names | scores | logfoldchanges | pvals | pvals_adj |
|---|---|---|---|---|
| Cd74 | 10.98096 | 2.915869 | 0 | 0 |
| Serpina3n | 11.48777 | 2.064526 | 0 | 0 |
| C4b | 22.08805 | 1.753775 | 0 | 0 |
4.17 OPC
| names | scores | logfoldchanges | pvals | pvals_adj |
|---|---|---|---|---|
| Cd74 | 22.063580 | 5.299099 | 0.0000000 | 0.0000000 |
| Cxcl10 | 4.022185 | 4.074791 | 0.0000577 | 0.0002300 |
| C4b | 28.681534 | 3.342240 | 0.0000000 | 0.0000000 |
| Serpina3n | 21.517027 | 3.116985 | 0.0000000 | 0.0000000 |
| Ly9 | 5.846620 | 3.035228 | 0.0000000 | 0.0000000 |
| Cst7 | 5.871054 | 2.952172 | 0.0000000 | 0.0000000 |
| Clec7a | 7.447059 | 2.937019 | 0.0000000 | 0.0000000 |
| C3 | 5.330118 | 2.827415 | 0.0000001 | 0.0000005 |
| Ctss | 22.755754 | 2.662425 | 0.0000000 | 0.0000000 |
| C1qa | 10.651853 | 2.084364 | 0.0000000 | 0.0000000 |
| Spp1 | 9.045135 | 1.947595 | 0.0000000 | 0.0000000 |
| Atf3 | 3.494980 | 1.814261 | 0.0004741 | 0.0016932 |
| Itgam | 3.553034 | 1.801209 | 0.0003808 | 0.0013798 |
| Lgals3 | 4.560864 | 1.729119 | 0.0000051 | 0.0000218 |
| Inpp5d | 6.757185 | 1.680977 | 0.0000000 | 0.0000000 |
| Cspg5 | -31.098356 | -1.623373 | 0.0000000 | 0.0000000 |
| Ctsc | 2.822587 | 1.622701 | 0.0047638 | 0.0146128 |
| Gfap | 17.763878 | 1.505473 | 0.0000000 | 0.0000000 |
| Trem2 | 3.999100 | 1.340515 | 0.0000636 | 0.0002503 |
| Cldn11 | 12.248850 | 1.325029 | 0.0000000 | 0.0000000 |
| Icam1 | 3.458820 | 1.303741 | 0.0005425 | 0.0019239 |
| Egr1 | -9.152687 | -1.290269 | 0.0000000 | 0.0000000 |
| Ptpru | -16.821754 | -1.281802 | 0.0000000 | 0.0000000 |
| Rph3a | -20.120094 | -1.276112 | 0.0000000 | 0.0000000 |
| Cspg4 | -27.315598 | -1.266995 | 0.0000000 | 0.0000000 |
| Hpca | -11.625162 | -1.237670 | 0.0000000 | 0.0000000 |
| Bcan | -27.927422 | -1.218149 | 0.0000000 | 0.0000000 |
| Enpp6 | 3.793122 | 1.152743 | 0.0001488 | 0.0005551 |
| Klk6 | 2.773283 | 1.132912 | 0.0055494 | 0.0168287 |
| Adrb1 | -3.040492 | -1.126666 | 0.0023619 | 0.0076958 |
| Cacng4 | -24.494429 | -1.126192 | 0.0000000 | 0.0000000 |
| Pdgfra | -22.711110 | -1.126121 | 0.0000000 | 0.0000000 |
| Olig1 | -28.010956 | -1.103647 | 0.0000000 | 0.0000000 |
| Grm4 | -5.235609 | -1.084730 | 0.0000002 | 0.0000008 |
| Syp | -19.167921 | -1.073679 | 0.0000000 | 0.0000000 |
| Grin2b | -7.905853 | -1.073639 | 0.0000000 | 0.0000000 |
| Rapgef3 | -21.003948 | -1.056739 | 0.0000000 | 0.0000000 |
| Cdh9 | -3.278109 | -1.045031 | 0.0010450 | 0.0035306 |
| Id4 | -4.865310 | -1.042507 | 0.0000011 | 0.0000051 |
| Nefm | -14.248327 | -1.040641 | 0.0000000 | 0.0000000 |
| Itgax | 2.479415 | 1.003834 | 0.0131598 | 0.0378155 |
| Scn4b | -5.939970 | -1.000151 | 0.0000000 | 0.0000000 |
4.18 Pericyte
| names | scores | logfoldchanges | pvals | pvals_adj |
|---|---|---|---|---|
| Cd74 | 7.313498 | 2.096242 | 0.00e+00 | 0.0000000 |
| C4b | 4.340364 | 1.114589 | 1.42e-05 | 0.0001922 |
4.19 Pvalb GABA
| names | scores | logfoldchanges | pvals | pvals_adj |
|---|---|---|---|---|
| Cd74 | 5.515627 | 2.760391 | 0.0e+00 | 3.0e-07 |
| Egr1 | -10.065308 | -1.314686 | 0.0e+00 | 0.0e+00 |
| Fos | -6.761326 | -1.251861 | 0.0e+00 | 0.0e+00 |
| Lamp5 | -4.470774 | -1.025050 | 7.8e-06 | 5.9e-05 |
| Adrb1 | -6.606277 | -1.004922 | 0.0e+00 | 0.0e+00 |
4.20 Sst GABA
| names | scores | logfoldchanges | pvals | pvals_adj |
|---|---|---|---|---|
| Egr2 | -3.166410 | -2.114153 | 0.0015433 | 0.0065954 |
| Cd74 | 3.100242 | 2.043140 | 0.0019336 | 0.0081245 |
| Fos | -10.758125 | -1.968860 | 0.0000000 | 0.0000000 |
| Egr1 | -12.888699 | -1.667493 | 0.0000000 | 0.0000000 |
| Adrb1 | -6.002086 | -1.198177 | 0.0000000 | 0.0000000 |
| Tpbg | 5.189824 | 1.084485 | 0.0000002 | 0.0000015 |
| Gfap | 7.948716 | 1.002401 | 0.0000000 | 0.0000000 |
4.21 STR Neuron
| names | scores | logfoldchanges | pvals | pvals_adj |
|---|---|---|---|---|
| Egr2 | -15.252028 | -2.046400 | 0.0000000 | 0.0000000 |
| Wnt2 | -22.535799 | -1.943914 | 0.0000000 | 0.0000000 |
| Htr2c | -8.654650 | -1.461609 | 0.0000000 | 0.0000000 |
| Egr4 | -26.267267 | -1.341182 | 0.0000000 | 0.0000000 |
| Sox8 | -38.576256 | -1.340200 | 0.0000000 | 0.0000000 |
| Fosl2 | -14.712869 | -1.325358 | 0.0000000 | 0.0000000 |
| Nnat | -16.401468 | -1.313548 | 0.0000000 | 0.0000000 |
| Otof | -18.600405 | -1.291863 | 0.0000000 | 0.0000000 |
| Id4 | -31.579699 | -1.215291 | 0.0000000 | 0.0000000 |
| Cspg5 | -41.360348 | -1.206559 | 0.0000000 | 0.0000000 |
| Ccnb2 | -2.707878 | -1.177844 | 0.0067715 | 0.0158850 |
| Dlk1 | -3.762596 | -1.176348 | 0.0001682 | 0.0004645 |
| Gfap | 16.617020 | 1.154274 | 0.0000000 | 0.0000000 |
| Fos | -11.743439 | -1.145487 | 0.0000000 | 0.0000000 |
| Gpr63 | -13.070436 | -1.135917 | 0.0000000 | 0.0000000 |
| Ntng1 | -8.895514 | -1.107336 | 0.0000000 | 0.0000000 |
| Ndufa4l2 | -3.067918 | -1.092639 | 0.0021556 | 0.0052067 |
| Cd74 | 4.845804 | 1.081961 | 0.0000013 | 0.0000038 |
| Rasgrf2 | -11.626558 | -1.081005 | 0.0000000 | 0.0000000 |
| Adrb1 | -22.502580 | -1.062318 | 0.0000000 | 0.0000000 |
| Nr4a1 | -24.893328 | -1.061485 | 0.0000000 | 0.0000000 |
| Fosb | -11.564626 | -1.019287 | 0.0000000 | 0.0000000 |
| Npy1r | -7.798757 | -1.017111 | 0.0000000 | 0.0000000 |
| Ccdc153 | -2.605158 | -1.014229 | 0.0091832 | 0.0208709 |
| Grm3 | -33.070084 | -1.006981 | 0.0000000 | 0.0000000 |
4.22 SUB Glut
| names | scores | logfoldchanges | pvals | pvals_adj |
|---|---|---|---|---|
| Cxcl10 | 3.855326 | 4.024214 | 0.0001156 | 0.0009473 |
| Cd74 | 4.258404 | 3.719672 | 0.0000206 | 0.0001906 |
| Htr1a | -3.803162 | -3.447729 | 0.0001429 | 0.0010823 |
| Gad1 | -2.816806 | -3.217809 | 0.0048504 | 0.0247468 |
| Egr4 | -5.289810 | -2.702437 | 0.0000001 | 0.0000019 |
| Bcan | -6.475335 | -2.625699 | 0.0000000 | 0.0000000 |
| Cspg5 | -6.355596 | -2.352687 | 0.0000000 | 0.0000000 |
| Gpr37 | -2.579701 | -2.341383 | 0.0098886 | 0.0462083 |
| Tpbg | -3.053911 | -2.287496 | 0.0022588 | 0.0129816 |
| Ctss | 4.740912 | 2.169066 | 0.0000021 | 0.0000236 |
| C1qa | 2.935358 | 2.073810 | 0.0033316 | 0.0183056 |
| Fosb | -2.698254 | -2.061518 | 0.0069704 | 0.0331925 |
| Fam131a | -8.391142 | -2.048522 | 0.0000000 | 0.0000000 |
| Vgf | -9.370385 | -2.025132 | 0.0000000 | 0.0000000 |
| C4b | 2.750417 | 2.013255 | 0.0059520 | 0.0288930 |
| Olig1 | -2.591556 | -1.979323 | 0.0095543 | 0.0450674 |
| Sst | -3.525750 | -1.951085 | 0.0004223 | 0.0028924 |
| Kcnh7 | -5.180742 | -1.930994 | 0.0000002 | 0.0000028 |
| Elfn1 | -6.406574 | -1.904427 | 0.0000000 | 0.0000000 |
| Adrb1 | -3.920529 | -1.868130 | 0.0000884 | 0.0007617 |
| Syp | -8.678039 | -1.829211 | 0.0000000 | 0.0000000 |
| Scn4b | -5.714228 | -1.776210 | 0.0000000 | 0.0000002 |
| Kcnab1 | -6.031949 | -1.767018 | 0.0000000 | 0.0000000 |
| Lratd2 | -3.723732 | -1.738506 | 0.0001963 | 0.0014225 |
| Gabra1 | -5.424960 | -1.712346 | 0.0000001 | 0.0000009 |
| Eno2 | -8.003475 | -1.697508 | 0.0000000 | 0.0000000 |
| Prkce | -3.668013 | -1.684378 | 0.0002444 | 0.0017214 |
| Hpca | -7.758072 | -1.658655 | 0.0000000 | 0.0000000 |
| Grm4 | -4.445717 | -1.655440 | 0.0000088 | 0.0000912 |
| Sox8 | -3.815018 | -1.639205 | 0.0001362 | 0.0010475 |
| Gja1 | -4.972089 | -1.628194 | 0.0000007 | 0.0000077 |
| Dkk3 | -7.084694 | -1.619981 | 0.0000000 | 0.0000000 |
| Nrg3 | -6.066329 | -1.596105 | 0.0000000 | 0.0000000 |
| Pde11a | -3.160608 | -1.574169 | 0.0015744 | 0.0091535 |
| Fos | -3.703578 | -1.558526 | 0.0002126 | 0.0015184 |
| Psen2 | -2.940101 | -1.551981 | 0.0032811 | 0.0182281 |
| Dlg4 | -7.803122 | -1.534408 | 0.0000000 | 0.0000000 |
| Htr5a | -2.870155 | -1.533630 | 0.0041027 | 0.0217557 |
| Egr1 | -6.263125 | -1.514333 | 0.0000000 | 0.0000000 |
| Ppp1r1b | -5.257801 | -1.482707 | 0.0000001 | 0.0000020 |
| Chrm4 | -3.980991 | -1.481933 | 0.0000686 | 0.0006020 |
| Nefm | -7.404786 | -1.449955 | 0.0000000 | 0.0000000 |
| Gria1 | -7.134486 | -1.440787 | 0.0000000 | 0.0000000 |
| Grin2a | -5.995197 | -1.427760 | 0.0000000 | 0.0000000 |
| Rph3a | -6.456366 | -1.427725 | 0.0000000 | 0.0000000 |
| Hrh3 | -2.750417 | -1.419643 | 0.0059520 | 0.0288930 |
| Neurod6 | -3.378745 | -1.418038 | 0.0007282 | 0.0046678 |
| Gpr158 | -3.618221 | -1.399720 | 0.0002966 | 0.0020600 |
| Syn1 | -7.023047 | -1.381249 | 0.0000000 | 0.0000000 |
| Cx3cl1 | -7.363292 | -1.371256 | 0.0000000 | 0.0000000 |
| Kcnd2 | -3.212771 | -1.339038 | 0.0013146 | 0.0078251 |
| Cnr1 | -2.925874 | -1.324338 | 0.0034349 | 0.0186679 |
| Arc | -5.805513 | -1.315159 | 0.0000000 | 0.0000001 |
| Grb2 | -4.343761 | -1.315120 | 0.0000140 | 0.0001401 |
| Ntng2 | -2.867783 | -1.310559 | 0.0041336 | 0.0217557 |
| Cplx1 | -7.255410 | -1.309365 | 0.0000000 | 0.0000000 |
| Ddit3 | 3.407197 | 1.301511 | 0.0006563 | 0.0043180 |
| Rbfox3 | -6.050917 | -1.288186 | 0.0000000 | 0.0000000 |
| Grin2b | -6.105451 | -1.286515 | 0.0000000 | 0.0000000 |
| Syngap1 | -6.641308 | -1.284447 | 0.0000000 | 0.0000000 |
| Gfap | 4.339019 | 1.263877 | 0.0000143 | 0.0001403 |
| Tbr1 | -2.560733 | -1.220888 | 0.0104452 | 0.0483572 |
| Epha10 | -3.845841 | -1.175429 | 0.0001201 | 0.0009628 |
| Fn1 | -3.276790 | -1.170132 | 0.0010499 | 0.0064811 |
| Fosl2 | -5.055076 | -1.153369 | 0.0000004 | 0.0000052 |
| Nr4a2 | -6.242972 | -1.152081 | 0.0000000 | 0.0000000 |
| Camk2a | -5.261357 | -1.151298 | 0.0000001 | 0.0000020 |
| Crhr1 | -3.843470 | -1.106770 | 0.0001213 | 0.0009628 |
| Neto1 | -5.511503 | -1.106329 | 0.0000000 | 0.0000006 |
| Slc17a7 | -6.110193 | -1.094327 | 0.0000000 | 0.0000000 |
| Csf1r | 2.968553 | 1.092889 | 0.0029921 | 0.0168093 |
| Hcn1 | -5.014769 | -1.082623 | 0.0000005 | 0.0000063 |
| Pdgfa | -3.983362 | -1.080629 | 0.0000679 | 0.0006020 |
| Lynx1 | -5.211565 | -1.076340 | 0.0000002 | 0.0000025 |
| Epha7 | -3.883778 | -1.069280 | 0.0001028 | 0.0008570 |
| Ptpru | -3.733217 | -1.051279 | 0.0001890 | 0.0013901 |
| Cck | -4.272630 | -1.050309 | 0.0000193 | 0.0001822 |
| App | -7.203247 | -1.046736 | 0.0000000 | 0.0000000 |
| Grm2 | -3.475958 | -1.034469 | 0.0005090 | 0.0034394 |
| Fezf2 | -5.066931 | -1.014270 | 0.0000004 | 0.0000051 |
4.23 TH Neuron
| names | scores | logfoldchanges | pvals | pvals_adj |
|---|---|---|---|---|
| Cd74 | 20.283000 | 4.144462 | 0.0000000 | 0.0000000 |
| Clec7a | 5.017197 | 2.693154 | 0.0000005 | 0.0000021 |
| Spp1 | 10.799181 | 2.535002 | 0.0000000 | 0.0000000 |
| Ctss | 18.911268 | 2.177782 | 0.0000000 | 0.0000000 |
| C1qa | 6.249269 | 1.654239 | 0.0000000 | 0.0000000 |
| Gfap | 19.100382 | 1.636467 | 0.0000000 | 0.0000000 |
| Cox6a2 | -5.455903 | -1.534525 | 0.0000000 | 0.0000002 |
| Bcan | -16.649742 | -1.328575 | 0.0000000 | 0.0000000 |
| Itga7 | -13.342796 | -1.271336 | 0.0000000 | 0.0000000 |
| C4b | 3.158005 | 1.243737 | 0.0015885 | 0.0049333 |
| Adrb1 | -14.787244 | -1.238746 | 0.0000000 | 0.0000000 |
| Sox8 | -4.416718 | -1.233021 | 0.0000100 | 0.0000377 |
| Cspg5 | -16.573458 | -1.187774 | 0.0000000 | 0.0000000 |
| Inpp5d | 2.972330 | 1.173289 | 0.0029555 | 0.0089021 |
| C3 | 4.039569 | 1.165907 | 0.0000535 | 0.0001886 |
| Ngf | -6.835734 | -1.160955 | 0.0000000 | 0.0000000 |
| Htr5a | -4.322067 | -1.152700 | 0.0000155 | 0.0000564 |
| Csf1r | 7.813028 | 1.149611 | 0.0000000 | 0.0000000 |
| Ntng2 | -2.692629 | -1.138832 | 0.0070891 | 0.0201395 |
| Car4 | -11.091613 | -1.122126 | 0.0000000 | 0.0000000 |
| Sorl1 | -8.363807 | -1.109907 | 0.0000000 | 0.0000000 |
| Fosl2 | -3.111117 | -1.092463 | 0.0018638 | 0.0057525 |
| Egr1 | -14.975497 | -1.051914 | 0.0000000 | 0.0000000 |
| Prkce | -9.713602 | -1.046305 | 0.0000000 | 0.0000000 |
| Grm4 | -17.761087 | -1.026480 | 0.0000000 | 0.0000000 |
| Gpr63 | -7.396331 | -1.019211 | 0.0000000 | 0.0000000 |
| Adarb2 | -10.372215 | -1.019042 | 0.0000000 | 0.0000000 |
| Coch | -6.796173 | -1.017654 | 0.0000000 | 0.0000000 |
| Fos | -10.408340 | -1.016051 | 0.0000000 | 0.0000000 |
| Dkk3 | -2.517688 | -1.000801 | 0.0118128 | 0.0322754 |
4.24 Vip_Lamp5_Sncg GABA
| names | scores | logfoldchanges | pvals | pvals_adj |
|---|---|---|---|---|
| Cd74 | 4.028603 | 2.287394 | 0.0000561 | 0.0002953 |
| Arc | -8.919403 | -1.129473 | 0.0000000 | 0.0000000 |
| Gfap | 10.678942 | 1.117905 | 0.0000000 | 0.0000000 |
| Gpr63 | -4.094939 | -1.112987 | 0.0000422 | 0.0002246 |
| Bcan | -5.627124 | -1.053312 | 0.0000000 | 0.0000001 |
| Cspg5 | -12.678706 | -1.041377 | 0.0000000 | 0.0000000 |
| Crebbp | -2.775224 | -1.018875 | 0.0055164 | 0.0227949 |
| Fos | -5.714624 | -1.010770 | 0.0000000 | 0.0000001 |
4.25 VLMC
| names | scores | logfoldchanges | pvals | pvals_adj |
|---|---|---|---|---|
| C3 | 2.998382 | 2.311522 | 0.0027142 | 0.0242337 |
| Nr4a1 | -6.931097 | -1.662902 | 0.0000000 | 0.0000000 |
| Nr4a2 | -4.254446 | -1.545675 | 0.0000210 | 0.0003613 |
| Egr1 | -3.512555 | -1.191276 | 0.0004438 | 0.0050434 |
| Cd74 | 8.197221 | 1.154254 | 0.0000000 | 0.0000000 |
| Hs3st1 | -3.973159 | -1.095896 | 0.0000709 | 0.0010430 |
| Plagl1 | -3.333734 | -1.089891 | 0.0008569 | 0.0087437 |
| Camk2a | -3.939495 | -1.044447 | 0.0000817 | 0.0011665 |
| Npy1r | -3.071756 | -1.036848 | 0.0021280 | 0.0197041 |
Abbreviation
Cell types & Regions
Astro, Astrocyte;
ABC, arachnoid barrier cells;
BAM, border-associated macrophages;
BLA, Basolateral amygdala;
CB, cerebellum;
CGE, caudal ganglionic eminence;
CHOR, choroid plexus;
CNU, cerebral nuclei;
CR, Cajal–Retzius;
CT, corticothalamic;
CTX, cerebral cortex;
CTXsp, cortical subplate;
DC, dendritic cells;
DCO, dorsal cochlear nucleus;
DG, dentate gyrus;
EA, extended amygdala;
Endo, endothelial cells;
ENT, Entorhinal area;
ENTl, Entorhinal area, lateral part;
Epen, ependymal;
EPI, epithalamus;
ET, extratelencephalic;
GC, granule cell;
HB, hindbrain;
HPF, hippocampal formation;
HY, hypothalamus;
HYa, anterior hypothalamic;
IMN, immature neurons;
IT, intratelencephalic;
L6b, layer 6b;
LGE, lateral ganglionic eminence;
LH, lateral habenula;
LSX, lateral septal complex;
MB, midbrain;
MGE, medial ganglionic eminence;
MH, medial habenula;
MM, medial mammillary nucleus;
MY, medulla;
NN, non-neuronal;
NP, near-projecting;
NT, non-telencephalon;
OB, olfactory bulb;
OEC, olfactory ensheathing cells;
OLF, olfactory areas;
Oligo, oligodendrocytes;
OPC, oligodendrocyte precursor cells;
P, pons;
PAL, pallidum;
Peri, pericytes;
PIR, piriform cortex;
SMC, smooth muscle cells;
STR, striatum;
TE, telencephalon;
TH, thalamus;
UBC, unipolar brush cells;
VLMC, vascular leptomeningeal cells.
Neurotransmitter types
Chol, cholinergic;
Dopa, dopaminergic;
GABA, GABAergic;
Glut, glutamatergic;
Glyc, glycinergic;
Hist, histaminergic;
Nora, noradrenergic;
Sero, serotonergic